Cigarette Smoke Induces Human Epidermal Receptor 2–Dependent Changes in Epithelial Permeability
نویسندگان
چکیده
منابع مشابه
Cigarette smoke induces senescence in alveolar epithelial cells.
Cellular senescence is a state of irreversible growth arrest induced either by telomere shortening (replicative senescence) or by telomere-independent signals (stress-induced senescence). The alveolar epithelium is often injured by a variety of inhaled toxins, including cigarette smoke (CS). In the present study, we investigated whether exposure to CS induces senescence of alveolar epithelial c...
متن کاملCigarette smoke extract induces differential expression levels of beta-defensin peptides in human alveolar epithelial cells
BACKGROUND The damaging effects of cigarette smoke on the lungs are well known in terms of cancer risks. Additional molecular changes within the lung tissue can also occur as a result of exposure to cigarette smoke. The human β-defensin (hBD) class of antimicrobial peptides is the focus of our research. In addition to antimicrobial activity, β-defensins also have immunomodulatory functions. Ove...
متن کاملCigarette smoke induces cellular senescence.
Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States, and cigarette smoking is the major risk factor for COPD. Fibroblasts play an important role in repair and lung homeostasis. Recent studies have demonstrated a reduced growth rate for lung fibroblasts in patients with COPD. In this study we examined the effect of cigarette smoke extract (CSE) ...
متن کاملCigarette smoke extract increases C5a receptor expression in human bronchial epithelial cells.
We have shown that exposing human bronchial epithelial cells (HBECs) to 5% cigarette smoke extract (CSE) up-regulates C5a anaphylatoxin receptor (C5aR) expression as determined by flow cytometric analysis and immunohistochemistry. In this study, we conducted whole-cell saturation studies to quantitate the receptor number. After exposing an HBEC line (BEAS-2B) to CSE, radiolabeled C5a bound satu...
متن کاملHuman Alveolar Epithelial Cell Injury Induced by Cigarette Smoke
BACKGROUND Cigarette smoke (CS) is a highly complex mixture and many of its components are known carcinogens, mutagens, and other toxic substances. CS induces oxidative stress and cell death, and this cell toxicity plays a key role in the pathogenesis of several pulmonary diseases. METHODOLOGY/PRINCIPAL FINDINGS We studied the effect of cigarette smoke extract (CSE) in human alveolar epitheli...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Respiratory Cell and Molecular Biology
سال: 2016
ISSN: 1044-1549,1535-4989
DOI: 10.1165/rcmb.2014-0437oc